The 2025 NFL season has officially kicked off, and the Kansas City Chiefs, a team that has dominated the league in recent years, remain the center of attention. With the official schedule released, we can see a challenging yet promising journey ahead for the Chiefs. Based on the schedule you provided, I’ll analyze each phase of the season, offer predictions for key matchups, and assess the Chiefs’ chances of defending their throne this year. Let’s dive in!
Early Season: A Strong Start But Not Without Challenges
The Chiefs’ season begins on September 5 with a home game against the Los Angeles Chargers (LAC). This Thursday Night Football matchup, kicking off at 7:00 PM, promises an emotional night for fans. The Chargers are always a tough divisional rival in the AFC West, especially with their potent offense led by quarterback Justin Herbert. However, with the home-field advantage and the experience of Patrick Mahomes and Coach Andy Reid, I predict the Chiefs will secure a close victory, likely 27-24.
Next, on September 14, the Chiefs travel to face the Philadelphia Eagles (PHI). This 3:25 PM game will be a tough test, as the Eagles boast a versatile offense and a stout defense. With potential weather challenges in Philadelphia during September (it can be quite humid), the Chiefs might struggle. The Eagles could capitalize on their home advantage to pressure Mahomes. I predict a narrow loss for the Chiefs, 20-23.
In Week 3, the Chiefs return home to take on the New York Giants (NYG) on September 21 at 7:20 PM. The Giants aren’t a powerhouse, especially if they’re still rebuilding. With the support of the home crowd and the Chiefs’ explosive offense, I expect an easy win, 34-17.
Mid-Season: A Series of Tests
Week 4 brings a tough road game against the Baltimore Ravens (BAL) on September 28 at 3:25 PM. This is one of the Chiefs’ most challenging matchups in the first half of the season. The Ravens, known for their run-heavy style and strong defense, are always a formidable opponent. I foresee a tight game, but the Ravens’ defense might stifle Mahomes just enough to edge out a win, 24-27.
In Week 5, the Chiefs return home to face the Jacksonville Jaguars (JAX) on October 6, a Monday Night Football matchup at 7:15 PM. This is a chance for the Chiefs to regain momentum. The Jaguars are still building their roster, and I don’t think they’ll have enough to upset the Chiefs. Prediction: Chiefs win, 31-20.
Weeks 6 and 7 see the Chiefs facing the Detroit Lions (DET) on October 12 and the Las Vegas Raiders (LV) on October 19. The Lions game, a 7:20 PM road matchup, could be tricky with Detroit’s youthful offense, but I believe the Chiefs will prevail, 28-21. The Raiders game, a 12:00 PM home matchup, should be more straightforward, with the Chiefs leveraging their home advantage for a 35-24 win.
Week 8 pits the Chiefs against the Washington Commanders (WAS) on the road on October 27, a Monday Night Football game at 7:16 PM. The Commanders can be unpredictable, but with the Chiefs’ experience, I predict a 30-20 victory.
Late Season: The Sprint to the Finish
After their bye week in Week 10, the Chiefs return in Week 11 to face the Denver Broncos (DEN) on the road on November 16 at 3:25 PM. The Broncos are a pesky divisional rival in the AFC West, but I think the Chiefs will pull out a 27-21 win.
Weeks 12 and 13 bring road games against the Indianapolis Colts (IND) and Dallas Cowboys (DAL). The Colts matchup on November 23 at 12:00 PM should be relatively easy, with the Chiefs winning 31-17. However, the Thanksgiving Day game against the Cowboys on November 27 at 3:30 PM will be tougher. The Cowboys have a potent offense, and I predict a close loss for the Chiefs, 24-27.
In Weeks 14 and 15, the Chiefs return home to face the Houston Texans (HOU) on December 7 and the Las Vegas Raiders (LAC) on December 14. The Texans game could be competitive, but I believe the Chiefs will win 28-24. The Raiders game should be an easier victory, with a predicted score of 34-20.

The Final Stretch: High Stakes and Challenges
Weeks 16 and 17 feature matchups against the Tennessee Titans (TEN) and the Denver Broncos (DEN). The Titans game on December 21 at 12:00 PM at home should be a comfortable win, 33-17. However, the Christmas Day game against the Broncos on December 25 at 7:16 PM on the road will be tougher. I predict a narrow Chiefs victory, 24-21.
Finally, in Week 18, the Chiefs face the Las Vegas Raiders (LV) again, with the date still TBD. This game will be crucial for the Chiefs to solidify their playoff position. I predict a 31-20 win.
Conclusion and Overall Prediction
Based on this schedule, I predict the Kansas City Chiefs will finish the regular season with a 13-4 record. They’ll face challenges against strong teams like the Ravens, Eagles, and Cowboys, but with Patrick Mahomes’ talent and Andy Reid’s coaching, the Chiefs remain a top contender for the 2025 Super Bowl. Defending their throne won’t be easy, but the Chiefs have the firepower to overcome the obstacles. What do you think of this prediction? Let me know your thoughts!